Despite the body's competence to maintain the integrity of the epithelium, the intestine is vulnerable to breaches that can trigger inflammatory responses. Induction of a localized intense inflammatory response is needed to entail disruption or invasion of the epithelial barrier. The onset and period of an chronic inflammatory response is limited, yet in some instances persistent immune activation promotes intense intestinal inflammation, resulting in detrimental pathological consequences.
Inflammation is defined as the composition of immunologic events in response to a variety of damaging stimuli, including tissue injury and infection. The signature clues of extreme local inflammation are swelling, heat, pain, redness, and loss of function. Colon inflammation is characterized by infiltration of the mucosa by leukocytes, damage to the epithelium and lamina propria matrix, and loss of normal nutrient absorptive function. Although extreme inflammation is primarily focused on resolution of a local event, the process is also accompanied by a systemic chronic phase response, which is mediated by the action of cytokines produced within the mucosa that diffuse through the vasculature. As a matter of fact, the structure of events characteristic of colon inflammation involve local vasodilation of small vessels within the mucosa, chemotatic signaling and recruitment of circulating leukocytes, and subsequent leukocytic infiltration and activation that ultimately promotes resolution of the inciting event and promotes tissue healing.
An acute colorectal inflammatory response can be triggered by multiple stimuli. In the gastrointestinal tract, stimuli include infectious pathogens, chemical irritation, and food allergy. In addition, an effective iatrogenic factors of mucosal inflammation include radiation damage, drug reactions, ischemia, and treatment-induced pathology, such as pseudomembranous colitis and ulceration induced by nonsteroidal anti-inflammatory (NSAID) agents. While the mechanisms of action of factors forming intestinal inflammation are not absolutely understood, several common features and mediators of severe intestinal inflammation have been identified.
Acute colorectal inflammation developes as a result of persistent immune response, either due to continual presence of an antigen or dysregulation of the immune response. While neutrophils play a central role in severe inflammation, intensification and activation of T cells and macrophages is the commomly known of extreme intestinal inflammation. Initially the insult is contained, neutrophils are no longer recruited, and their presence is diminisheddiminished. If the site becomes chronically inflamed, monocytes, macrophages, lymphocytes, and plasma cells predominate in the lesion. The monocytes and macrophages provide two vital functions during the severe state. In the beginning, they phagocytose remaining debris or pathogens unattended by the neutrophils, and second, they modulate T cell function through antigen presentation and cytokine secretion.
Inflammation inside the gut develops as an outcome of interactions between somatic intestinal cells, such as IEC and fibroblasts, and effect or cells of the innate and adaptive arms of the immune system. These interactions are mediated by both soluble factors and cell-to-cell contact. Extreme colorectal inflammation is either resolved or develops into extreme intestinal inflammatory reactions, which can result in fibrosis and loss of function. Understanding the molecular and cellular events in intestinal inflammation aids in efforts to develop new approaches to control the pathologic effects of inflammation.
Most people probably heard about an annual medical checkups after the age of 40 for colon cancer. Prevention is always way better than a cure, why wait till age 40 for colon screening if there are historic cancer trends within family history. As a matter of fact, ensuring the colon is performing at healthy condition is highly essential. Chronic inflammation could already occur inside your colon without you realizing it.
In conclusion, this is trigger by a cumulative of harmful toxins inside the colon. In addition, an excessive infestation of harmful bacteria & other micro organism are causing oxidative stress in your colon which will ultimately lead to colon inflammation. Colon cleansing is worth considering if you are new or just learn about this remedy. Always use only natural product while performing colon cleansing.