Pseudomembranous colitis is an inflammatory condition of the colon that occurs mostly in adults who have received antibiotics. Common symptoms of this condition include watery diarrhea; abdominal cramps; high fever; urgency for bowel movement; nausea; dehydration; and blood, pus or mucous in the stools. Antibiotic use, age over 65 years, a weakened immune system, inflammatory bowel diseases, colorectal cancer, intestinal surgery and cancer chemotherapy, are risk factors for this condition.

The Ayurvedic treatment of pseudomembranous colitis is aimed at controlling the diarrhea, reducing inflammation in the intestines and preventing complications like perforation. Ayurvedic medicines like Kutaj-Ghan-Vati, Kutaj-Parpati, Praval-Panchamrut, Panchamrut-Parpati, Kutajarishta, Bilva-avaleha and Laghu-Sutshekhar-Ras are used to treat the diarrhea. Herbal medicines which can be used for this purpose include Vishwa (Zinziber officinalis), Musta (Cyperus rotundus), Bilva (Aegle marmelos), Dadim (Pomegranate), Maiphal (Quercus infectoria), Jaiphal (Myristica fragrans), Lavang (Eugenia caryophyllata), Haridra (Curcuma longa) and Daruharidra (Berberis aristata).

Patients who do not respond to the above mentioned medicines can be given additional medicines like Saariva (Hemidesmus indicus), Usheer (Vetiveria zizanioidis), Rakta-Chandan (Pterocarpus santalinus), Pittapapda (Fumaria vaillantii), Shankh-Bhasma and Praval-Bhasma. Medicines like Kamdudha-Ras and Yashtimadhuk (Glycerrhiza glabra) can be used to prevent perforation in the intestine. Medicines like Ras-Parpati, Kutaj-Parpati and Panchamrut-Parpati are effective both for treating the diarrhea as well as helping the normal bacteria to grow again in the intestines.

Patients affected with pseudomembranous colitis have a tendency to relapse several times. Medicines like Panchamrut-Parpati and Suvarna-Parpati can be given to prevent this. Medicines like Bilva-avaleha and Kutajarishta can also be given for this purpose on a long term basis. Pomegranate juice, curd and buttermilk are recommended for this condition. It is important to treat dehydration in order to prevent complications like circulatory collapse, toxic megacolon and kidney failure.

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